From the discovery of Hendra virus in Australia in 1994 to the ongoing outbreaks of MERS virus in the Middle East, we have witnessed the emergence of several important new infectious diseases in the last two decades. Many of them are bat-borne zoonotic agents, including Hendra, Nipah, Ebola, Marburg, SARS and probably MERS as well. Due to their acute nature of infection, and unpredictable and rare occurrence, conventional vaccination strategy applied to most infectious diseases are less suitable for this class of highly lethal zoonotic infections. In this presentation, I will review the current status of bat-borne emerging viruses and discuss some unique features of bats which may explain why bats are increasingly recognized as one of the most important reservoir hosts for zoonotic viruses. I will conclude by presenting a novel One-Health approach to the development of a recombinant-subunit vaccine to minimize and prevent Hendra virus outbreaks in both horse and human populations.