Antimicrobial Resistance is a growing problem that is reaching crisis proportions nationally and globally in both hospitals and the community. As practicing microbiologists we need to think carefully on how to use and report laboratory microbiology data and molecular tests, to inform of therapeutic guidelines and infection control practices. Often we are asked to choose simplicity over complexity and sometimes we are asked to acknowledge our fundamental ignorance of many of the specifics of antibiotic-microorganism interactions. Antimicrobial resistance detection and therapeutic choices often rely on strategies that require an understanding of developed rapid and reliable microbiology assays, evidence based recommendations on appropriate duration of therapy and laboratory markers in infection control practices.