Trichuris (whipworm) infects 1
billion people worldwide, and causes a disease (trichuriasis) that results in major
socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested
in bloody diarrhoea, and chronic disease can cause malnourishment and stunting
in children. Paradoxically,
Trichuris of pigshas shown substantial promise as a treatment for human autoimmune
disorders, including inflammatory bowel disease (IBD) and multiple sclerosis
(MS). Here, we report ~80
megabase (Mb) draft assemblies of the genomes of adult male and female T. suis,and explore stage-, sex- and tissue-specific transcription of messenger
and small non-coding RNAs.